Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys
Identifieur interne : 004C39 ( Main/Exploration ); précédent : 004C38; suivant : 004C40Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys
Auteurs : M. Guttman [Canada] ; V. W. Yong [Canada] ; S. U. Kim [Canada] ; D. B. Calne [Canada] ; W. R. W. Martin [Canada] ; M. J. Adam [Canada] ; T. J. Ruth [Canada]Source :
- Synapse [ 0887-4476 ] ; 1988.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Corpus Striatum (drug effects), Corpus Striatum (metabolism), Dopamine (metabolism), Functional Laterality (drug effects), In vivo detection, Injections, Intravenous, Macaca fascicularis, Nigrostriatal injury, Parkinson Disease, Secondary (metabolism), Parkinsonism, Pyridines (toxicity), Tomography, Emission-Computed.
- MESH :
- chemical , metabolism : Dopamine.
- chemical , toxicity : Pyridines.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug effects : Corpus Striatum, Functional Laterality.
- metabolism : Corpus Striatum, Parkinson Disease, Secondary.
- Animals, Injections, Intravenous, Macaca fascicularis, Tomography, Emission-Computed.
Abstract
In cynomolgus monkeys, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MRTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro‐L‐dopa (6‐FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6‐FD and PET.
Url:
DOI: 10.1002/syn.890020502
Affiliations:
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Guttman</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Yong, V W" sort="Yong, V W" uniqKey="Yong V" first="V. W." last="Yong">V. W. Yong</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Kim, S U" sort="Kim, S U" uniqKey="Kim S" first="S. U." last="Kim">S. U. Kim</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Martin, W R W" sort="Martin, W R W" uniqKey="Martin W" first="W. R. W." last="Martin">W. R. W. Martin</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Adam, M J" sort="Adam, M J" uniqKey="Adam M" first="M. J." last="Adam">M. J. Adam</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>The UBC/TRIUMF PET Project, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>The UBC/TRIUMF PET Project, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Synapse</title><title level="j" type="abbrev">Synapse</title><idno type="ISSN">0887-4476</idno><idno type="eISSN">1098-2396</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1988">1988</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="469">469</biblScope><biblScope unit="page" to="473">473</biblScope></imprint><idno type="ISSN">0887-4476</idno></series><idno type="istex">568D6B4C5922E173A92D81AA6BF369466FB5B4D6</idno><idno type="DOI">10.1002/syn.890020502</idno><idno type="ArticleID">SYN890020502</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-4476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (metabolism)</term><term>Dopamine (metabolism)</term><term>Functional Laterality (drug effects)</term><term>In vivo detection</term><term>Injections, Intravenous</term><term>Macaca fascicularis</term><term>Nigrostriatal injury</term><term>Parkinson Disease, Secondary (metabolism)</term><term>Parkinsonism</term><term>Pyridines (toxicity)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pyridines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Injections, Intravenous</term><term>Macaca fascicularis</term><term>Tomography, Emission-Computed</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In cynomolgus monkeys, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MRTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro‐L‐dopa (6‐FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6‐FD and PET.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></noRegion><name sortKey="Adam, M J" sort="Adam, M J" uniqKey="Adam M" first="M. J." last="Adam">M. J. Adam</name><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><name sortKey="Kim, S U" sort="Kim, S U" uniqKey="Kim S" first="S. U." last="Kim">S. U. Kim</name><name sortKey="Martin, W R W" sort="Martin, W R W" uniqKey="Martin W" first="W. R. W." last="Martin">W. R. W. Martin</name><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name><name sortKey="Yong, V W" sort="Yong, V W" uniqKey="Yong V" first="V. W." last="Yong">V. W. Yong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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